Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-<em>N</em>-substituted amino- and 5-benzoyl-<em>N</em>-sulfonylamino-4-alkylsulfanyl-2-pyridones
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چکیده
منابع مشابه
Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones
The present research describes the synthesis of novel 5-benzoyl-N-substituted-amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones 5a-c and 6a-c via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles 2a-c with N-cyanoacetohydrazide 3 and cyanoaceto-N-phenylsulfonylhydrazide 4, respectively. Also, the reactivity of the compounds 5a-c toward hydrazine hydrate to give product 1...
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In order to find novel chitin synthesis inhibitors (CSIs) with good activity, benzoylphenylurea, a typical kind of CSIs, was chosen as the lead compound and 15 novel derivatives containing furan moieties were designed by converting the urea linkage of benzoylphenylureas into a semicarbazide and changing the aniline part into furoyl groups. The title compounds were synthesized by the reaction of...
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In the title mol-ecule, C(17)H(13)FN(2)O(2), the 3,4-dihydro-pyrimidine ring adopts a flattened sofa conformation with the flap atom (which bears the fluoro-phenyl substituent) deviating from the plane defined by the remaining five ring atoms by 0.281 (2) Å. This plane forms dihedral angles of 85.98 (6) and 60.63 (6)° with the 4-fluoro-phenyl and benzoyl-phenyl rings, respectively. The dihedral...
متن کامل3-Benzoyl-5-chlorouracil
THE DIHEDRAL ANGLE BETWEEN THE PLANES OF TWO AROMATIC RINGS IN THE TITLE COMPOUND [SYSTEMATIC NAME: 3-benzoyl-5-chloro-pyrimidine-2,4(1H,3H)-dione], C(11)H(7)ClN(2)O(3), is 86.79 (6)°. Centrosymmetric dimers formed by N-H⋯O hydrogen bonds are linked through C-H⋯O inter-actions, forming a two-dimensional network parallel to (10).
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The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2017
ISSN: 1177-8881
DOI: 10.2147/dddt.s149615